Yes, during whole journey we shall be taking halts in majorly famous cities and before reaching or Manali / Srinagar too to acclimatise.Don't even try to play with AMS issues as it can be serious for someone with co travellers, if not you.
Even if you have to use Plan B via Manali try to stay in hills before Manali for 1 night and next night at Jispa and then move to Leh and keep eye on news of route open closure. Manali may be having good rush during weekends. If you are there then avoid Manlai and stay at Kullu or ahead of Manali only.
You may have to move to Leh earlier and can spend 1 night only at hills of Himachal Pradesh then keep 2 days & night at Leh for rest.
Since our co-travellers/Pilots/Navigators are female so definitely sufficient journey breaks have to taken to keep them healthy.